Primary bile acid biosynthesis
| PAG Title | Primary bile acid biosynthesis |
| PAG ID | WIG000594 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine. |
| Species | Homo sapiens |
| nCoCo Score | 954 |
| Base PAG ID | WIG000594 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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